Nanoscale Biophysics & Biomedicine Laboratory

West China Medical Center, Sichuan University

Publications

Selective Publications

  1. Zhang M#, Tang C#, Wang Z#, Chen S#, Zhang D, Li K, Sun K, Zhao C, Wang Y, Xu M, Dai L, Lu G, Shi H, Ren H, Chen L*, Geng J*. Real-time detection of 20 amino acids and discrimination of pathologically relevant peptides with functionalized nanopore. Nature Methods. Apr;21(4):609-618. (2024)
  2. Chi P#, Wang X#, Li J#, Yang H#, Li K#, Zhang Y#, Lin S, Yu L, Liu S, Chen L, Ren R, Wu J*, Huang Z*, Geng J*, Deng D*. Molecular insights into the inhibition of proton-activated chloride channel by transfer RNA. Cell Research Oct;34(10):743-745. (2024)
  3. Lin JW#*, Tang C#, Wei HC#, Du B#, Chen C#, Wang M#, Zhou Y#, Yu MX#, Cheng L#, Kuivanen S#, Ogando NS, Levanov L, Zhao Y, Li CL, Zhou R, Li Z, Zhang Y, Sun K, Wang C, Chen L, Xiao X, Zheng X, Chen SS, Zhou Z, Yang R, Zhang D, Xu M, Song J, Wang D, Li Y, Lei S, Zeng W, Yang Q, He P, Zhang Y, Zhou L, Cao L, Luo F, Liu H, Wang L, Ye F, Zhang M, Li M, Fan W, Li X, Li K, Ke B, Xu J, Yang H, He S, Pan M, Yan Y, Zha Y, Jiang L, Yu C, Liu Y, Xu Z, Li Q, Jiang Y, Sun J, Hong W, Wei H, Lu G, Vapalahti O, Luo Y, Wei Y, Connor T, Tan W, Snijder EJ, Smura T*, Li W*, Geng J*, Ying B*, Chen L*. Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response. Cell Host & Microbe. 29, 489-502 (2021)
  4. Mou L#, Ke M#, Song M#, Shan Y#, Xiao Q, Liu Q, Li J, Sun K, Pu L, Guo L, Geng J*, Wu J*, Deng D*. Structural basis for gating mechanism of Pannexin 1 channel. Cell Research. doi: 10.1038/s41422-020-0313-x (2020)
  5. Sun K#, Zhao C#, Zeng X#, Chen Y#, Jiang X#, Ding X, Gou L, Xie H, Li X, Zhang X, Lin S, Dou L, Wei L, Niu H, Zhang M, Tian R, Sawyer E, Yuan Q, Huang Y, Chen P, Zhao C, Zhou C, Ying Y, Shi B, Wei X, Jiang R, Zhang L*, Lu G*, Geng J*. Active DNA unwinding and transport by a membrane-adapted helicase nanopore. Nature Communications. 10,5083 (2019)
  6. Geng J#, Kim KH#, Zhang J, Escalada A, Tunuguntla R, Comolli LR, Allen FI, Shnyrova AV, Cho KR, Munoz D, Wang YM, Ajo-Franklin CM, Frolov VA, Noy A*. Stochastic transport in carbon nanotubes in lipid membranes and live cell membranes. Nature 514, 612 (2014) NatureAsia《自然》研究亮点、《Nature Methods》研究聚焦述评
  7. Haque H, Geng J, Montemagno CD, Guo P*. Incorporation of a viral DNA-packaging motor channel in lipid bilayers towards real-time single-molecule sensing of chemicals and double-stranded DNA. Nature Protocols 8, 373 (2013)
  8. Geng J, Fang H, Haque F, Zhang L, Guo P*. Three reversible and controllable discrete steps of channel gating of a viral DNA packaging motor. Biomaterials 32, 8234 (2011) 入选年度封面 Biomaterials 2011 – The Year in Images
  9. Wendell D#, Jing P#, Geng J, Lee TJ, Subramaniam V, Montemagno CD, Guo P*. Translocation of double-stranded DNA through membrane adapted phi29 motor protein nanopore. Nature Nanotechnology 4, 765 (2009)